EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis
Sybille Brochard, Alison Vanlaeys, Mahdia Taieb, Isabelle Richard, Juliette Aury‐Landas, Benoı̂t Bernay, Julien Pontin, Célia Seillier, Nina Bon, Baptiste Picart, Claire Pecqueur, Olivier Toutirais, Claire S. Vinatier, Jérôme Guicheux, Eric Maubert, , Catherine Baugé
This study shows EZH2 inhibition reduces cartilage damage, synovial inflammation, and pain in OA by modulating inflammatory, neuroimmune, and osteoimmune pathways.
bioRxiv · Jan 19, 2025 · PreprintPhysiology