Author

Olivier Toutirais

InsermORCID 0000-0002-9591-8548Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Catherine BaugéiD· 2 shared Célia SeillieriD· 2 shared Karim BoumédieneiD· 2 shared Sybille BrochardiD· 2 shared Alison Vanlaeys· 1 shared Baptiste PicartiD· 1 shared Benoı̂t BernayiD· 1 shared Brigitte Le MauffiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersPhysiology

Catherine BaugéORCID

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2 papers

Recent·Most cited

Systemic immune alterations in a murine experimental model of osteoarthritis

Célia Seillier, Sybille Brochard, Karim Boumédiene, Denis Vivien, Brigitte Le Mauff, Olivier Toutirais, Catherine Baugé

This study profiles systemic immune changes in a murine OA model, finding reduced MHCII on macrophages and DCs, increased tolerogenic DCs, and shifts in T cell composition.

bioRxiv · Nov 22, 2025 · PreprintPhysiology

EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis

Sybille Brochard, Alison Vanlaeys, Mahdia Taieb, Isabelle Richard, Juliette Aury‐Landas, Benoı̂t Bernay, Julien Pontin, Célia Seillier, Nina Bon, Baptiste Picart, Claire Pecqueur, Olivier Toutirais, Claire S. Vinatier, Jérôme Guicheux, Eric Maubert, , Catherine Baugé

This study shows EZH2 inhibition reduces cartilage damage, synovial inflammation, and pain in OA by modulating inflammatory, neuroimmune, and osteoimmune pathways.

bioRxiv · Jan 19, 2025 · PreprintPhysiology