Aliya Norton

Cell type-resolved connectomic reconstruction of the spinal dorsal horn reveals sensory neuron synaptic organization and modality-specific inhibition

The paper presents tools to reconstruct spinal cord circuits and identifies modality-specific inhibitory synapses between sensory neurons and inhibitory neurons.

A synaptic wiring diagram underlying modality-specific ascending pathways of the superficial spinal dorsal horn

The paper maps synaptic connections in the mouse spinal dorsal horn to show how different sensory modalities are routed through distinct pathways to the brain.

Purkinje cell collaterals preferentially target a subtype of molecular layer interneuron

The paper investigates Purkinje cell connectivity to molecular layer interneuron subtypes and finds that PCs preferentially synapse onto MLI2s and disinhibit MLI1s, revealing feedback pathways that modulate PC firing.

Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons

The paper demonstrates that networks of molecular layer interneurons use ephaptic signals to control Purkinje cell firing timing in vivo.

Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells

The paper investigates how climbing fiber inputs selectively excite disinhibitory interneurons to enhance dendritic calcium signaling in Purkinje cells, supporting cerebellar learning.

Processing reliant on granule cells is essential for motor learning but dispensable for many cerebellar-dependent behaviors

The paper shows that granule cell signaling is essential for motor learning but not for many cerebellar-dependent behaviors, while Purkinje cell signaling affects both motor learning and other behaviors.

Cerebellar circuits for disinhibition and synchronous inhibition

The paper identifies two MLI subtypes with distinct connectivity and functional roles in cerebellar circuits, showing how disinhibition gates cerebellar-dependent learning.