Elizabeth P. Lackey

Purkinje cell collaterals preferentially target a subtype of molecular layer interneuron

The paper investigates Purkinje cell connectivity to molecular layer interneuron subtypes and finds that PCs preferentially synapse onto MLI2s and disinhibit MLI1s, revealing feedback pathways that modulate PC firing.

Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons

The paper demonstrates that networks of molecular layer interneurons use ephaptic signals to control Purkinje cell firing timing in vivo.

Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells

The paper investigates how climbing fiber inputs selectively excite disinhibitory interneurons to enhance dendritic calcium signaling in Purkinje cells, supporting cerebellar learning.

Cerebellar circuits for disinhibition and synchronous inhibition

The paper identifies two MLI subtypes with distinct connectivity and functional roles in cerebellar circuits, showing how disinhibition gates cerebellar-dependent learning.

Maturation of Purkinje cell firing properties relies on granule cell neurogenesis

This study shows that granule cell neurogenesis is essential for the maturation of Purkinje cell firing properties and cerebellar-dependent behaviors in postnatal mice.

Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules that are defined by distinct pinceau sizes

The paper shows that Purkinje cell neurotransmission organizes basket cell pinceaux into distinct size-based zones.

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells

The paper investigates how inhibitory molecular layer interneurons influence Purkinje cell firing properties in mice by selectively depleting GABAergic neurotransmission from stellate or basket cells.