Compensatory mechanisms render Tcf7l1a dispensable for eye formation despite its requirement in eye field specification
Rodrigo Young, Thomas A. Hawkins, Florencia Cavodeassi, Heather L. Stickney, Quenten Schwarz, Lisa M. Lawrence, Claudia Wierzbicki, Bowie Yik-Ling Cheng, Jingyuan Luo, Elizabeth Mayela Ambrosio, Allison Klosner, Ian M. Sealy, Jasmine Rowell, Chintan A. Trivedi, Isaac Henry Bianco, , Stephen W. Wilson
The paper shows that Tcf7l1a is essential for eye field specification in zebrafish but not for eye development, as mutants develop normal eyes through compensatory mechanisms.
eLife · Feb 18, 2019Peer-reviewedDevelopmental Biology