Ian M. Sealy

Loss of slc39a14 causes simultaneous manganese deficiency and hypersensitivity in zebrafish

The paper identifies manganese deficiency and neurotoxicity in zebrafish slc39a14 mutants through transcriptome analysis, revealing key molecular pathways involved in manganese homeostasis disruption.

The gene regulatory basis of genetic compensation during neural crest induction

The paper identifies the core gene module required for neural crest induction and reveals the transcriptional basis of genetic compensation via paralogues in zebrafish.

Compensatory mechanisms render Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

The paper shows that Tcf7l1a is essential for eye field specification in zebrafish but not for eye development, as mutants develop normal eyes through compensatory mechanisms.

A high-resolution mRNA expression time course of embryonic development in zebrafish

RNA-seq and 3′ end counting over 18 zebrafish stages (1-cell to day 5) profile 23,642 genes; over 100 chromosome 4 zinc finger genes peak at zygotic genome activation.