Stephen W. Wilson

A novel pipeline for the validation of manganese chelators for the treatment of manganese overload

This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.

Genetically interacting mutations and mechanical stress affect the stochasticity of developmental eye defects in yap1 mutants

The paper investigates stochastic developmental eye defects in zebrafish yap1 mutants, showing genetic and mechanical factors influence penetrance of retinal coloboma.

Optic nerve innervation promotes Wnt/b-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

The paper investigates how optic nerve innervation affects Wnt/b-catenin pathway activity and progenitor cell proliferation in zebrafish optic tectum, showing that innervation promotes survival and proliferation even in darkness.

Re-purposing Ac/Ds transgenic system for CRISPR/dCas9 modulation of enhancers and non-coding RNAs in zebrafish

The paper adapts the Ac/Ds transposition system to enable CRISPR/dCas9 interference for studying non-coding RNAs and enhancers in zebrafish without altering genetic sequences.

Foxd1 dependent induction of temporal retinal character is required for visual function

This study shows that Foxd1 is required for temporal retinal character, which is essential for the development of the high acuity area and visual function in zebrafish.

A Drosophila glial cell atlas reveals a mismatch between detectable transcriptional diversity and morphological diversity

The paper generates a Drosophila glial cell atlas and finds that transcriptional diversity does not match morphological diversity across glial classes.

A structural atlas of the developing zebrafish telencephalon based on spatially-restricted transgene expression

The paper maps the development of cell populations in the zebrafish telencephalon during eversion using transgene expression and creates a structural atlas.

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

This study identifies Cachd1 as a novel Wnt receptor-interacting protein essential for left-right neuronal asymmetry in zebrafish.

Loss of slc39a14 causes simultaneous manganese deficiency and hypersensitivity in zebrafish

The paper identifies manganese deficiency and neurotoxicity in zebrafish slc39a14 mutants through transcriptome analysis, revealing key molecular pathways involved in manganese homeostasis disruption.

A red herring in zebrafish genetics: allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants

The paper shows that in zebrafish, differentially expressed genes near a mutation may not be caused by the mutation due to allele-specific expression, leading to misinterpretation of RNA-seq results.

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

This paper introduces a CRISPR-Cas9 method for rapid generation of F0 biallelic knockouts in zebrafish, enabling quick screening of complex phenotypes.

The GINS complex is required for the survival of rapidly proliferating retinal and tectal progenitor cells during zebrafish development

This study shows that the GINS complex is essential for DNA replication in rapidly dividing retinal and tectal progenitor cells in zebrafish, leading to apoptosis in these cells when GINS function is absent.

Developmentally regulated tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

The paper identifies tcf7l2 splice variants that mediate repressor functions in eye formation by interacting with Tle co-repressors and phosphorylated residues.

Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry

The paper shows that Sox1a in parapineal cells is required for imparting left-type molecular and connectivity features to the habenula, establishing a link between parapineal formation and habenular asymmetry.

Compensatory mechanisms render Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

The paper shows that Tcf7l1a is essential for eye field specification in zebrafish but not for eye development, as mutants develop normal eyes through compensatory mechanisms.

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits.

This study identifies Slbp as essential for cell cycle exit and neuronal differentiation in zebrafish, leading to retinal and brain defects.

Development of social behaviour in young zebrafish.

This study identifies the developmental stage at which zebrafish develop social preferences and interactions, showing that 3-week-old fish exhibit strong social preference while 1-week-old fish do not.