Control of lumen geometry and topology by the interplay between pressure and cell proliferation rate in pancreatic organoids
Byung Ho Lee, Kana Fuji, Heike Petzold, Philip Allan Seymour, Siham Yennek, Coline Schewin, Allison Lewis, Daniel Riveline, Tetsuya Hiraiwa, Masaki Sano, Anne Grapin‐Botton
The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.
Nature Cell Biology · Dec 19, 2025Peer-reviewedDevelopmental Biology