Masaki Sano

Control of lumen geometry and topology by the interplay between pressure and cell proliferation rate in pancreatic organoids

The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.

Predicting Organoid Morphology Through a Phase Field Model: Insights into Cell Division and Lumenal Pressure

This paper uses a phase field model to predict organoid morphology by simulating cell division and lumenal pressure, identifying key parameters that determine shape and structure.

Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure

The paper compares lumen nucleation and fusion dynamics in three epithelial organoid systems under varying hydrostatic pressure conditions, revealing conserved self-organisation rules.

Integer topological defects provide a new way to quantify and classify cell sheets

The paper induces +1 topological defects in neural progenitor cell monolayers and shows cells are attracted to their cores, challenging existing theories about active nematics.

The interplay between lumen pressure and cell proliferation determines organoid morphology in a multicellular phase field model

This paper develops a multicellular phase field model to simulate organoid morphology by integrating lumen pressure and cell proliferation, revealing how these factors determine organoid shapes and phenotypes.