Tetsuya Hiraiwa

The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.

This paper measures force scaling in microtubule swarms driven by kinesin motors, showing quantitative scalability and linking collective organization to mechanical performance.

The paper investigates the spatiotemporal dynamics of lumen formation in mammalian follicles, revealing a critical phenomenon involving fluid networks and cell death.

This paper uses a phase field model to predict organoid morphology by simulating cell division and lumenal pressure, identifying key parameters that determine shape and structure.

The paper compares lumen nucleation and fusion dynamics in three epithelial organoid systems under varying hydrostatic pressure conditions, revealing conserved self-organisation rules.

This paper develops a continuum framework to study stress anisotropy in 3D curved biological layers, showing how curvature and cell mechanics lead to irregular cellular shapes like scutoids.

This study develops a 3D vertex model to analyze multicellular tissue mechanics, revealing strain softening and hysteresis during large deformations.

This study identifies the neuronal mechanisms underlying rheotaxis in the pre-vertebrate chordate Ciona intestinalis using behavioral analysis and computational modeling.

This study identifies a mechanism for epithelial stratification analogous to a phase transition, driven by foam-geometric instability and nucleation-growth processes.

The paper develops a model combining active fluid theory with experimental data to predict cell shape changes in epithelial tissues.

This paper develops a multicellular phase field model to simulate organoid morphology by integrating lumen pressure and cell proliferation, revealing how these factors determine organoid shapes and phenotypes.