Siham Yennek

The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.

The paper compares lumen nucleation and fusion dynamics in three epithelial organoid systems under varying hydrostatic pressure conditions, revealing conserved self-organisation rules.

The paper shows that apical restriction of VANGL in pancreatic ducts is essential for epithelial integrity, with loss of restriction causing cell death and extrusion.