Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence
Jeffery L. Dunning, Max Kreifeldt, Agbonlahor Okhuarobo, Catherine Lopez, Florence P. Varodayan, Michal Bajo, R MAINS SMITH, Celeste Moreau, Colton Krull, Leeann Shu, Allison White, Giovana C. Macedo, Harpreet Sidhu, Howard C. Becker, Marisa Roberto, , Candice Contet
This study identifies PSTN Crh neurons as a key driver of alcohol drinking escalation in dependence, showing their role shifts from inhibitory to stimulatory with dependence.
bioRxiv · May 5, 2026 · PreprintNeuroscience