Juliana M. Xavier-Ferrucio

Integrating Human Genetics and Protective Genome Editing to Enable ADGRE2-Directed AML Therapy

This study evaluates ADGRE2 as an AML target, showing efficient gene editing in HSPCs to protect against myelotoxicity and developing ADGRE2-specific CAR T cells for therapy.

A resource and computational approach for quantifying gene editing allelism at single-cell resolution

The paper constructs a single-cell DNA sequencing atlas and introduces GUMM, a computational workflow, to accurately infer gene editing allelism despite technical artifacts.

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

The paper reconstructs a sparsely interconnected transcriptional hierarchy in leukemia cells stabilized by incoherent feed-forward loops and shows inhibitors disrupt core regulators' programs.

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

The paper identifies a modular core regulatory circuitry in AML that enforces oncogene expression in KMT2A-rearranged leukemias.

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms

The paper co-sequences microRNAs and mRNAs in single cells to show miRNA variability contributes to non-genetic cell-to-cell heterogeneity and identifies new regulatory relationships.