Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors
Taku Harada, Monika W. Perez, Jérémie Kalfon, Flora Dievenich Braes, Rashad Batley, Kenneth Eagle, Behnam Nabet, Becky S. Leifer, Jasmin A. Kruell, Vikram R. Paralkar, Kimberly Stegmaier, Angela N. Koehler, Stuart H. Orkin, Maxim Pimkin
The paper benchmarks six MYB inhibitors using a nascent transcriptomics assay, revealing partial specificity, off-target activity, and mixed agonism-antagonism effects.
bioRxiv · Apr 7, 2023 · PreprintMolecular Biology