NF-kB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Stiffened Lung
Erica M. Orsini, Adam M. Boulton, Susamma Abraham, Alyson Brown, Haley Ricci, Akash Ahuja, Bishnu Datt Pant, Caitlin M. Snyder, Amanda Reinhardt, Amy Houghton Attaway, Ryan J. Musich, Lisa M. Grove, Mitchell A. Olman, Vidula Vachharajani, Rachel Greenberg Scheraga
This study shows that NF-kB-dependent transcription of Piezo1 in macrophages enhances bacterial clearance during pneumonia by promoting lysosome biogenesis and stiffness-dependent phagolysosome maturation.
bioRxiv · Nov 6, 2025 · PreprintImmunology