An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching
Youjia Guo, Hyun Hyung An, Katelyn Toohill, Sneha Ramesh Mani, Ten D. Li, Chantal K. Diallo, Diego Antonio Jimenez, Alyssa Saito, Nicolae Adrian Leu, Beril Tore, Jamie Yoon Ha, Vamshidhar C. Nallamala, Sarah Stanger, Piotr Tetlak, Yanlin Hou, , Andrew J. Modzelewski
This study identifies an intronic SINE element that regulates Pou5f1/OCT4 repression in mouse trophectoderm, linking hormone signaling to blastocyst hatching and implantation.
bioRxiv · Aug 26, 2026 · PreprintDevelopmental Biology