Nicolae Adrian Leu

An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching

This study identifies an intronic SINE element that regulates Pou5f1/OCT4 repression in mouse trophectoderm, linking hormone signaling to blastocyst hatching and implantation.

Generation of spermatogonia from pluripotent stem cells in humans and non-human primates

This study generates spermatogonia from human and non-human primate pluripotent stem cells using xenogeneic testes, providing models for male infertility research.

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML

This paper identifies dual inhibition of LSD1 and Menin as a promising therapeutic strategy for non-APL AML by inducing terminal differentiation through distinct molecular mechanisms.

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

This study shows MOV10 restricts LINE1 retrotransposition in mice in a dosage-dependent manner, affecting reproductive fitness and transcriptome regulation.

FRIZZLED 2 regulates limb development by mediating both β-catenin-dependent and independent Wnt signaling pathways

This study shows that FZD2 mutations cause limb defects by disrupting both canonical and non-canonical Wnt signaling, using genetic mouse models to establish causality in Robinow Syndrome and omodysplasia.

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated Regions

This study shows that TET1's catalytic activity is essential for reprogramming imprinting control regions and sperm-specific hypomethylated regions during germline development.

Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver Russell Syndrome-like mouse models

This study investigates the role of H19/Igf2 dysregulation in cardiac and placental defects in SRS-like mouse models, showing disrupted ECM and endothelial proliferation pathways.

YTHDC2 Is Essential for Pachytene Progression and Prevents Aberrant Microtubule-Driven Telomere Clustering in Male Meiosis

This study shows YTHDC2 is essential for meiotic pachytene progression by maintaining a meiotic transcriptome and preventing microtubule-driven telomere clustering.

C2CD6 is required for assembly of the CatSper calcium channel complex and fertilization

This study identifies C2CD6 as a novel subunit of the CatSper calcium channel complex, showing its role in sperm function and male fertility.