Author

Ten D. Li

Keio UniversityORCID 0000-0003-3971-6463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Youjia GuoiD· 4 shared Haruhiko SiomiiD· 3 shared Kensaku MuranoiD· 3 shared Tomohiro KitanoiD· 3 shared Akihiko SakashitaiD· 2 shared Hirotsugu Ishizu· 2 shared Alyssa Saito· 1 shared Ana Domingo-Meulas· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersDevelopmental Biology

Youjia GuoORCID

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4 papers

Recent·Most cited

Developmental BiologybioRxivPreprintAug 26, 2026

An Intronic SINE at Pou5f1 Links Hormone Signaling to Blastocyst Hatching

Youjia Guo, Hyun Hyung An, Katelyn Toohill…·Andrew J. Modzelewski

This study identifies an intronic SINE element that regulates Pou5f1/OCT4 repression in mouse trophectoderm, linking hormone signaling to blastocyst hatching and implantation.

DOI 10.64898/2026.08.25.747035

mousestatistical model

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Developmental BiologybioRxivPreprintAug 21, 2025

REFEE Shapes ZGA Through Post-Transcriptional Regulation of Repetitive RNAs in Mouse Embryos

Mie Kobayashi‐Ishihara, Akihiko Sakashita, Youjia Guo…·Haruhiko Siomi

This study identifies REFEE as a post-transcriptional regulator of repetitive RNAs that influences zygotic genome activation in mouse embryos.

DOI 10.1101/2025.08.21.671216

mousebulk RNA-seq

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Developmental BiologyeLifePeer-reviewedJun 10, 2024

Obox4 promotes zygotic genome activation upon loss of Dux

Youjia Guo, Tomohiro Kitano, Kimiko Inoue…·Haruhiko Siomi

The paper identifies Obox4 as a redundant transcription factor that promotes zygotic genome activation in mouse embryos, compensating for the loss of Dux.

47 citationstop 2%

mousebulk RNA-seq

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Developmental BiologyScience AdvancesPeer-reviewedNov 23, 2022

TDP-43 safeguards the embryo genome from L1 retrotransposition

Ten D. Li, Kensaku Murano, Tomohiro Kitano…·Haruhiko Siomi

This study shows that TDP-43 prevents L1 retrotransposition in mouse embryos and stem cells, protecting genome integrity.

29 citations

mouseDNA methylation

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