Youjia Guo

This study identifies an intronic SINE element that regulates Pou5f1/OCT4 repression in mouse trophectoderm, linking hormone signaling to blastocyst hatching and implantation.

This study identifies REFEE as a post-transcriptional regulator of repetitive RNAs that influences zygotic genome activation in mouse embryos.

The paper identifies Obox4 as a redundant transcription factor that promotes zygotic genome activation in mouse embryos, compensating for the loss of Dux.

This study shows that TDP-43 prevents L1 retrotransposition in mouse embryos and stem cells, protecting genome integrity.

This study shows that MERVL RNA is essential for proper regulation of the host transcriptome and chromatin state during early mouse embryo development, with knockdown causing embryonic lethality.