idh-1 neomorphic mutation confers sensitivity to vitamin B12 via increased dependency on one-carbon metabolism in Caenorhabditis elegans
Olga Ponomarova, Alyxandra N. Starbard, Alexandra C. Belfi, Amanda V. Anderson, Meera V. Sundaram, Albertha J.M. Walhout
This study shows that the idh-1neo mutation in C. elegans increases dependency on one-carbon metabolism, making the worms vulnerable to vitamin B12 deficiency and leading to embryonic lethality.
Life Science Alliance · Jul 15, 2024Peer-reviewedBiochemistry