Olga Ponomarova

Reflected Inline Detection in Epi Oblique Plane Microscopy

The paper introduces RIDE-OPM, a simplified OPM design that improves imaging stability and flexibility for long-term biological imaging.

Illuminating the renal response to pH stress with single-nucleus RNA sequencing

This study uses single-nucleus RNA sequencing to investigate sex-specific transcriptional responses of the kidney to acidosis and alkalosis in mice.

idh-1 neomorphic mutation confers sensitivity to vitamin B12 via increased dependency on one-carbon metabolism in Caenorhabditis elegans

This study shows that the idh-1neo mutation in C. elegans increases dependency on one-carbon metabolism, making the worms vulnerable to vitamin B12 deficiency and leading to embryonic lethality.

Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy

The paper shows that evolved bacterial resistance to gemcitabine can either reduce or increase its efficacy in the local environment by altering drug breakdown.

Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism

The paper shows that different bacteria modulate tamoxifen toxicity in C. elegans through fatty acid metabolism, with varying death mechanisms and FA profiles.

WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization

The paper manually annotates and visualizes metabolic pathways in C. elegans, providing pathway maps for metabolic enrichment analysis of transcriptomic data.

C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.

C. elegans Multidrug Resistance Protein 5 (MRP-5) Transports Vitamin B12 from the Intestine to the Gonad to Support Embryonic Development