Albertha J.M. Walhout

The paper shows that glycolytic specialization in two C. elegans neurons shapes their biophysical properties and functional roles in vivo.

The paper investigates tissue-specific metabolic functions of GPI-1 in C. elegans, showing isoform-specific localization and metabolic roles in different tissues.

The paper introduces Worm Perturb-Seq (WPS) to perform high-resolution RNA-seq on perturbed C. elegans, identifying gene regulatory networks and showing pairwise modularity in nuclear hormone receptor regulation.

This study shows that the idh-1neo mutation in C. elegans increases dependency on one-carbon metabolism, making the worms vulnerable to vitamin B12 deficiency and leading to embryonic lethality.

The paper identifies 216 regulatory interactions of transcriptional cofactors in C. elegans intestine using RNAi and fluorescent reporters.

The paper identifies widespread transcriptional regulation of metabolic genes in C. elegans and introduces a tool to explore gene-pathway associations.

The paper shows that evolved bacterial resistance to gemcitabine can either reduce or increase its efficacy in the local environment by altering drug breakdown.

The paper demonstrates how enzyme levels influence metabolic flux through three paradigms and introduces an algorithm to predict flux changes from enzyme expression in yeast and humans.

The paper shows that different bacteria modulate tamoxifen toxicity in C. elegans through fatty acid metabolism, with varying death mechanisms and FA profiles.

This study shows that vitamin B12-producing gut bacteria modulate excitatory neurotransmission in C. elegans by altering the methionine/SAM cycle and choline oxidation pathway.

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

The paper manually annotates and visualizes metabolic pathways in C. elegans, providing pathway maps for metabolic enrichment analysis of transcriptomic data.

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.

The paper identifies genetic modifiers of propionate sensitivity in C. elegans using genome-wide association mapping and shows that natural variation in GLCT-3 modulates this trait.

WormCat is a web-based tool for annotating and visualizing gene set enrichment in C. elegans datasets, identifying both known and novel biological categories.

The paper identifies a persistence detector in an animal that redirects propionate breakdown to a shunt pathway when flux through the canonical pathway is perturbed.