Intranasal HSV 1 Infection Drives Region Specific Interferon Dominant Microglial Remodeling
Seth E. Frietze, Cameron Lunn, Dean Oldham, Joseph R. Boyd, Andrew N. Bubak, Amalia Bustillos, Maria A. Nagel, Diego Restrepo, Kimberley D. Bruce, Christy S. Niemeyer
This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.
bioRxiv · Mar 23, 2026 · PreprintNeuroscience