Joseph R. Boyd

Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation

This study shows that type V collagen is essential for decidual ECM organization and angiogenesis during embryo implantation, with its absence causing pregnancy loss.

Intranasal HSV 1 Infection Drives Region Specific Interferon Dominant Microglial Remodeling

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia

This study identifies ERG as a vulnerability in IKZF1-mutated B-cell acute lymphoblastic leukemia through gene regulatory network analysis and functional validation.

Multiple long-range cis interactions generate CTCF insulator-dependent viral chromatin domains in quiescent HSV-1 genomes

The paper investigates how HSV-1 CTCF insulators regulate chromatin organization and transcription through long-range cis interactions, showing that deletion of the CTRL2 insulator disrupts chromatin domains and alters transcriptional accessibility.

Single-nucleus multiome ATAC and RNA sequencing reveals the molecular basis of thermal acclimation in Drosophila melanogaster embryos

The paper uses single-nucleus multiome sequencing to study how thermal acclimation affects chromatin accessibility and gene expression in Drosophila embryos, revealing homeostatic mechanisms that enhance heat tolerance.

Thyroid Hormone Dependent Transcriptional Programming by TRβ Requires SWI/SNF Chromatin Remodelers

The paper identifies three distinct modes of TRβ interaction with chromatin and shows differential recruitment of SWI/SNF complexes in response to thyroid hormone.