Christy S. Niemeyer

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human Microglia

This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.

Intranasal HSV 1 Infection Drives Region Specific Interferon Dominant Microglial Remodeling

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

Olfactory and Trigeminal Routes of HSV-1 CNS Infection with Regional Microglial Heterogeneity

This study tracks HSV-1 spread from the nasal passages to the CNS in mice, revealing region-specific infection patterns and microglial responses.

Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging

This study investigates age- and sex-related metabolic changes in female brains and microglia, finding that estrogen may suppress disease-associated microglia (DAM) factors, potentially increasing Alzheimer's disease risk in post-menopausal women.

Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease

The paper identifies viral infection and inflammation signatures in the olfactory system of familial Alzheimer's disease patients, suggesting their role in disease progression.

Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium

The paper identifies TRPM5-expressing microvillous cells in the olfactory epithelium as potentially involved in viral infection through transcriptional profiling.