PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS
Bart Nieuwenhuis, Amanda C. Barber, Rachel S Evans, Craig S. Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A. Hulshof, Andrew Osborne, Raquel Conceição, Tasneem Z. Khatib, Sarita S. Deshpande, Joshua Cave, Charles ffrench‐Constant, , Richard Eva
The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.
EMBO Molecular Medicine · Jun 17, 2020Peer-reviewedNeuroscience