Richard Eva

This study shows that increasing PI3K{delta} activity in adult rat cortical neurons promotes corticospinal tract regeneration and functional recovery after spinal cord injury.

The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.

This study shows that Protrudin, when overexpressed, supports axon regeneration in the adult central nervous system by acting as a scaffold to organize endoplasmic reticulum, integrins, and Rab11 endosomes in the distal axon.