James W. Fawcett

This study shows that 4-MU reduces PNNs, improves memory, and decreases neuroinflammation in aged mice.

This study investigates the relationship between autophagy and integrin dynamics in axon growth and regeneration, finding a bidirectional feedback system that regulates these processes.

This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.

This study shows that long-term PI3Kδ overexpression in adult rat cortex using AAV1 is safe and well-tolerated, with no adverse effects observed over one year.

This study investigates how mechanical properties of neural tissue change after injury, finding that PNS tissue stiffens while CNS tissue softens, potentially influencing regeneration.

This study shows that increasing PI3K{delta} activity in adult rat cortical neurons promotes corticospinal tract regeneration and functional recovery after spinal cord injury.

This study identifies a distinct CNS regeneration program activated by integrin expression in spinal cord sensory neurons, differing from PNS regeneration and involving ubiquitination, autophagy, and signaling pathways.

This paper demonstrates that expressing alpha 9 integrin and its activator kindlin-1 in sensory neurons enables axon regeneration through spinal cord injuries in rats, restoring sensory function.

This study examines the role of perineuronal nets (PNNs) in memory and learning after synaptic withdrawal induced by an hibernation-like state, finding that PNN absence affects synaptic restoration but not long-term memory storage.

The paper analyzes integrin expression in primary rat RPE cells and the human ARPE-19 cell line using immunochemistry, finding that both express integrins, with ARPE-19 increasing expression after long-term culturing.

The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.

This study shows that Protrudin, when overexpressed, supports axon regeneration in the adult central nervous system by acting as a scaffold to organize endoplasmic reticulum, integrins, and Rab11 endosomes in the distal axon.

The paper shows that restoring C6S levels in aged brains improves memory by reversing perineuronal net inhibition.