Bart Nieuwenhuis

RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

This study identifies RABGAP1 as a sensor that modulates APP trafficking and processing by regulating RAB activity on endosomal subdomains, with implications for Alzheimer's disease.

Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract

This study shows that increasing PI3K{delta} activity in adult rat cortical neurons promotes corticospinal tract regeneration and functional recovery after spinal cord injury.

Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity

This study identifies VMN, a metabolite of the pesticide vacor, as a potent SARM1 activator, showing that SARM1 removal rescues vacor-induced neuron and axon death.

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.

Restoring the pattern of perineuronal net sulphation corrects age-related memory loss

The paper shows that restoring C6S levels in aged brains improves memory by reversing perineuronal net inhibition.