A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity
Amit K Jaiswal, Georgia Scherer, Michelle L. Thaxton, Jacob P. Sorrentino, Constance Yuen, Milauni M. Mehta, Gunjan Sharma, Tasha Lotus Lin, Tiffany M. Tran, Amanda Cohen, Alexander J. Ritter, Rishi Sury Kotecha, Jeremy R. Sanford, Robert D. Damoiseaux, Neil K. Garg, Dinesh S. Rao
This paper identifies I3IN-002, a small molecule inhibitor of IGF2BP3, which shows anti-leukemic activity in cell lines and a mouse model.
Haematologica · Nov 27, 2025Peer-reviewedCancer Biology