Robert D. Damoiseaux

Dynamic regulation of single-cell contractile heterogeneity in the human trabecular meshwork

This study quantifies single-cell contractility in human trabecular meshwork cells under various conditions and finds that contractility is context-dependent, shaped by both extracellular and intracellular factors.

Automated DNA-Encoded Library Synthesis on Magnetic Anion Exchange Resin

This paper automates DNA-encoded library synthesis using magnetic anion exchange resin and a particle-handling instrument, enabling efficient and scalable DEL production.

Identification of Cysteine-Reactive Early Mitotic Inhibitors

This paper identifies novel early mitotic inhibitors using a cell-based high-content screening strategy with a cysteine-reactive compound library.

Key Regulatory Elements of the TGFbeta-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer Types

Multi-omics Reveals Divergent Endothelial Molecular Responses to New and Old World Hantaviruses

This study integrates multi-omics data to compare endothelial cell responses to New and Old World hantaviruses, identifying species-specific immune and cellular mechanisms.

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

Deformability screening identifies NUDT5 as a mediator of cellular mechanobiology

The paper screens compounds to identify mechanical mediators by measuring cell deformability, finding NUDT5 as a key mediator in ovarian cancer.

Natural compounds magnolol and dicoumarol enhance adipogenesis for future food applications

This study identifies magnolol and dicoumarol as natural compounds that enhance adipogenesis in multiple cell systems, offering potential for food applications and tissue engineering.

Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer

A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity

This paper identifies I3IN-002, a small molecule inhibitor of IGF2BP3, which shows anti-leukemic activity in cell lines and a mouse model.

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3

This study shows IGF2BP3 regulates RNA methylation by altering cellular metabolism to increase SAM production, enhancing m6A modifications and gene expression in leukemia.

Phosphatidylcholine Metabolism Controls Alveolar Progenitor Renewal and Pulmonary Fibrosis

This study identifies LPCAT1 as a critical regulator of AT2 cell renewal and lipid metabolism in IPF, showing that reactivating LPCAT1 can mitigate lung fibrosis.

Distinguish risk genes functioning at presynaptic or postsynaptic regions and key connectomes associated with pathological α-synuclein spreading

The paper identifies presynaptic and postsynaptic risk genes and key connectomes involved in pathological α-synuclein spreading using mathematical models and gene regulatory network analysis.

Drug screen reveals new potent host-targeted antivirals against Mpox virus

The paper identifies potent host-targeted antivirals against Mpox virus through high-throughput screening of a kinase inhibitor library, showing efficacy in vitro and in a mouse model.

Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma

The paper develops a novel urea-based compound, MXC-017, that crosses the blood-brain barrier, targets glioma stem cells, and improves survival in GBM models when combined with radiation.

Loss of Sarm1 Mitigates Axonal and Neuronal Degeneration and Promotes Neuronal Repair After Ischemic Stroke

This study shows that loss of Sarm1 reduces axonal degeneration and promotes neuronal repair after ischemic stroke by activating a pro-growth molecular program.

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

Building an atlas of mechanobiology: high-throughput contractility screen of 2418 kinase inhibitors in five primary human cell types reveals selective divergent responses among related cell types

The paper screens 2,418 kinase inhibitors across five human cell types to identify cell-type specific contractility responses and challenges assumptions about pathway conservation.

An activation-based high throughput screen identifies caspase-10 inhibitors

This study identifies caspase-10 inhibitors using an activation-based high-throughput screen, revealing inhibitors that preferentially target the zymogen form of caspase-10.

The Dopamine Receptor Antagonist TFP Prevents Phenotype Conversion and Improves Survival in Mouse Models of Glioblastoma

Prevalence and patterns of higher-order interactions

The paper studies higher-order interactions in antibiotic combinations on Escherichia coli and finds they increase in frequency with more drugs, showing net synergy and emergent antagonism.