Alexander J. Ritter

Virus-like antigen display delivers a stand-alone danger signal through the BCR that circumvents tolerance

The paper shows that virus-like particle-displayed antigens bypass BCR tolerance by triggering distinct signaling and transcriptional programs compared to soluble antigens.

A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity

This paper identifies I3IN-002, a small molecule inhibitor of IGF2BP3, which shows anti-leukemic activity in cell lines and a mouse model.

IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia

This study identifies IGF2BP3's role in modulating miRNA targeting in MLL-AF4 leukemia by competing with AGO2 for 3'-UTR binding, thereby reducing miR-181a-mediated repression of oncogenic mRNAs.

Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3

This study shows IGF2BP3 regulates RNA methylation by altering cellular metabolism to increase SAM production, enhancing m6A modifications and gene expression in leukemia.

Transcriptional control of central T cell tolerance by NR4A family nuclear receptors

This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.