Tiffany M. Tran

This paper identifies I3IN-002, a small molecule inhibitor of IGF2BP3, which shows anti-leukemic activity in cell lines and a mouse model.

This study shows IGF2BP3 regulates RNA methylation by altering cellular metabolism to increase SAM production, enhancing m6A modifications and gene expression in leukemia.

This study identifies distinct causes for three hematopoietic aging phenotypes using mouse models and single-cell analysis, showing HSC accumulation is NFκB-independent, functional impairment is HSC-autonomous NFκB-driven, and myeloid bias is driven by the NFκB-altered bone marrow environment.

This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.

This study shows that cGKII knockout mice exhibit altered ultrasonic vocalizations and hypothalamic neuron activation, suggesting they model speech impairment in human 4q21 microdeletion syndrome.