COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age
Titas Sengupta, Rachel L. Kaletsky, Katherine S. Morillo, Shiyi Zhou, Alan Brown, K. Novak, Ying-Ti Weng, Patrick Dougherty, Amayel Ka, Coleen Tara Murphy
This study identifies SET1/COMPASS-mediated de novo transcription as a mechanism accelerating forgetting with age in C. elegans and humans.
bioRxiv · Oct 31, 2025 · PreprintNeuroscience