Shiyi Zhou

This study uses long-read transcriptomes to identify ancestral spider silk proteins and their evolutionary trajectories, revealing how they diversified into modern silk types.

This study identifies SET1/COMPASS-mediated de novo transcription as a mechanism accelerating forgetting with age in C. elegans and humans.

Single-nucleus RNA sequencing of adult C. elegans neurons identifies transcriptional changes in daf-2 mutants related to chemosensation, learning, and memory.

The paper identifies LOAD risk genes through systems biology and shows their impact on memory function via neuronal endosomal dysfunction in C. elegans.

This study investigates the IIS/FOXO pathway's role in cognitive aging using C. elegans, finding that daf-2 mutants exhibit distinct transcriptomic changes that enhance neuronal resilience.

Activating the Gαq pathway in aged worms and mice improves memory and cognitive function, demonstrating conservation across species.

This study shows that hypodermal insulin/IGF-1 signaling regulates memory in C. elegans through non-autonomous signaling via the Notch pathway.

This study analyzes the transcriptomes of four major tissues in adult C. elegans to identify tissue-specific genes, isoforms, and regulatory patterns, providing a resource for understanding adult multicellular biology.