Rachel L. Kaletsky

Glial cells gate small RNA transport from germline to brain during transgenerational epigenetic inheritance of behavior

The paper identifies glial cells as the gatekeepers for small RNA transport from the germline to the nervous system in C. elegans, revealing a mechanism for transgenerational epigenetic inheritance of behavior.

Caenorhabditis elegans avoids Todstoff, a novel nociceptive necrotaxis cue

This study identifies Todstoff, a novel aversive cue in C. elegans that induces necrotaxis behaviors by signaling through ASH neurons and GPCR pathways.

COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age

This study identifies SET1/COMPASS-mediated de novo transcription as a mechanism accelerating forgetting with age in C. elegans and humans.

Single-Nucleus Neuronal Transcriptional Profiling of Male C. elegans Uncovers Regulators of Sex-Specific and Sex-Shared Behaviors

The paper profiles single-nucleus RNA sequencing data from male and hermaphrodite C. elegans neurons to identify sex-specific and sex-shared transcriptional regulators of behavior.

Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance

This paper identifies molecular mechanisms underlying transgenerational epigenetic inheritance of pathogen avoidance in C. elegans, showing that specific small RNAs from bacteria mediate this behavior across generations.

Adult Single-nucleus Neuronal Transcriptomes of Insulin Signaling Mutants Reveal Regulators of Behavior and Learning

Single-nucleus RNA sequencing of adult C. elegans neurons identifies transcriptional changes in daf-2 mutants related to chemosensation, learning, and memory.

Absence of Evidence is Not Evidence of Absence: The many flaws in the case against transgenerational epigenetic inheritance of pathogen avoidance in C. elegans

The paper critiques Gainey et al.'s failure to replicate transgenerational epigenetic inheritance experiments in C. elegans due to methodological deviations.

Pseudomonas fluorescens 15 small RNA Pfs1 mediates transgenerational epigenetic inheritance of pathogen avoidance in C. elegans through the Ephrin receptor VAB-1

The paper shows that PF15 small RNA Pfs1 induces transgenerational avoidance of PF15 in C. elegans by targeting the vab-1 Ephrin receptor gene, revealing a new bacterial sRNA/C. elegans gene target pair involved in pathogen avoidance.

The Neuron-specific IIS/FOXO Transcriptome in Aged Animals Reveals Regulatory Mechanisms of Neuronal and Cognitive Aging

This study investigates the IIS/FOXO pathway's role in cognitive aging using C. elegans, finding that daf-2 mutants exhibit distinct transcriptomic changes that enhance neuronal resilience.

A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance

The paper shows a bacterial small RNA induces transgenerational learned avoidance in C. elegans, with potential maladaptive effects on beneficial bacteria.

Neuronal Activation of the Gαq Protein EGL-30/GNAQ Late in Life Rejuvenates Cognition Across Species

Activating the Gαq pathway in aged worms and mice improves memory and cognitive function, demonstrating conservation across species.

Signaling from the C. elegans Hypodermis Non-autonomously Facilitates Short-term Associative Memory

This study shows that hypodermal insulin/IGF-1 signaling regulates memory in C. elegans through non-autonomous signaling via the Notch pathway.

GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson's disease

The paper introduces GAIT-GM, a Galaxy tool for multi-omics analysis, and finds a link between branched-chain amino acid metabolism and cholinergic neuron defects in a C. elegans Parkinson's disease model.

High-throughput behavioral screen in C. elegans reveals novel Parkinson disease drug candidates

The paper identifies four FDA-approved drugs, including metformin, as potential Parkinson's disease therapeutics using a high-throughput behavioral screen in C. elegans.

Horizontal and vertical transmission of transgenerational memories via the Cer1 transposon

The paper shows that C. elegans uses the Cer1 retrotransposon to transmit pathogen avoidance memories across generations through inter-tissue signaling.

Metabolic defects cause hyperactive mitochondria and Parkinson disease-like traits

This study shows that metabolic defects in C. elegans lead to hyperactive mitochondria and Parkinson's-like traits, with metformin improving motor function and reducing neurodegeneration.

C. elegans reads bacterial non-coding RNAs to learn pathogenic avoidance

This study shows that C. elegans uses bacterial non-coding RNAs to learn and transmit pathogenic avoidance behavior across generations.

CREB non-autonomously regulates Reproductive Aging through Hedgehog/Patched Signalling

This paper shows that CREB regulates reproductive aging in C. elegans by controlling a Hedgehog-related signaling factor, WRT-10, through the TGF-β Sma/Mab pathway in the hypodermis.

Profiling of presynaptic mRNAs reveals a role for axonal PUMILIOs in associative memory formation

The paper identifies presynaptic mRNAs in C. elegans and shows that puf-7/8 repress memory formation by regulating mff-1.

Cross-kingdom recognition of bacterial small RNAs induces transgenerational pathogenic avoidance

The paper shows that C. elegans uses bacterial small RNAs to induce transgenerational pathogenic avoidance without direct bacterial contact.

C. elegans pathogenic learning confers multigenerational pathogen avoidance

This study shows that C. elegans can transmit learned pathogenic avoidance behavior to multiple generations through epigenetic mechanisms, specifically involving the PRG-1/Piwi homolog.

Transcriptome Analysis of Adult C. elegans Cells Reveals Tissue-specific Gene and Isoform Expression

This study analyzes the transcriptomes of four major tissues in adult C. elegans to identify tissue-specific genes, isoforms, and regulatory patterns, providing a resource for understanding adult multicellular biology.