Potent and lasting seizure suppression by systemic delivery of antagomirs targeting miR-134 timed with blood-brain barrier disruption
Cristina Ruedell Reschke, Luiz Fernando Almeida Silva, Vamshidhar R. Vangoor, M. Rosso, Bastian David, Brenton Cavanagh, Niamh M. C. Connolly, Gerard P. Brennan, Amaya Sanz‐Rodriguez, Catherine Mooney, Amra Batool, Chris Greene, Marian Brennan, Ronán Michael Conroy, Theodor Rüber, , David Clifford Henshall
This study shows that systemic delivery of Ant-134, timed with BBB disruption after status epilepticus, suppresses seizures in mice with long-lasting effects.
bioRxiv · Oct 8, 2019 · PreprintNeuroscience