Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma
Jong Chul Park, Nandini Pal Basak, Mateo Useche, Jun Seok Park, M. S. Ganesh, Amritha G Prabha, Chandra Reddy JayaPrakash, Mark Alex Varvares, Lori J. Wirth, William C. Faquin, Satish Sankaran, Srinivas Vinod Saladi
This study shows that PI3K pathway alterations in HPV-negative HNSCC are linked to poor outcomes and immune suppression, and that inhibiting PI3K can enhance immune response.
bioRxiv · Jul 2, 2024 · PreprintCancer Biology