Author

Lori J. Wirth

Harvard UniversityORCID 0000-0002-2629-2289Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jong Chul ParkiD· 2 shared William C. FaquiniD· 2 shared Adam von Paternos· 1 shared Amritha G Prabha· 1 shared Annie LiiD· 1 shared Anthony John IafrateiD· 1 shared Atul K. Bhan· 1 shared Bianca L Gonda· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Jong Chul ParkORCID

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2 papers

Recent·Most cited

Reversible Downregulation of HLA Class I in Adenoid Cystic Carcinoma

Annie Li, Bianca L Gonda, Elizabeth M. Codd, Adam von Paternos, Dawn R. Mitchell, Markus D. Herrmann, Prinjali Kalyan, Samantha E. Flynn, Thuc Q Dzu, Chengzhuo Gao, Edwin Zhang, Julia J Mendel, Julia C Thierauf, Peter M. Sadow, Thomas Denize, , Anthony John Iafrate

This study identifies low HLA/B2M class I expression in ACC tumors and shows it can be reversed by interferon-ψ or STING agonists, suggesting a path for immunotherapy.

Journal for ImmunoTherapy of Cancer · Apr 1, 2025Peer-reviewedCancer Biology

Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma

Jong Chul Park, Nandini Pal Basak, Mateo Useche, Jun Seok Park, M. S. Ganesh, Amritha G Prabha, Chandra Reddy JayaPrakash, Mark Alex Varvares, Lori J. Wirth, William C. Faquin, Satish Sankaran, Srinivas Vinod Saladi

This study shows that PI3K pathway alterations in HPV-negative HNSCC are linked to poor outcomes and immune suppression, and that inhibiting PI3K can enhance immune response.

bioRxiv · Jul 2, 2024 · PreprintCancer Biology