Author

Mark Alex Varvares

Harvard UniversityORCID 0000-0002-6570-5672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Allen L. FengiD· 1 shared Amritha G Prabha· 1 shared Benedict Choi· 1 shared Chandra Reddy JayaPrakash· 1 shared Daniel G. Deschler· 1 shared Daniel L. FadeniD· 1 shared Derrick T. LiniD· 1 shared Fereydoun HormozdiariiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Allen L. FengORCID

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2 papers

Recent·Most cited

Orphan Non-Coding RNAs Drive Tumorigenesis and Enable Pre-Diagnostic Detection in HPV-Negative Head and Neck Cancer

Hoang C B Nguyen, Lishi Li, Benedict Choi, Mehran Karimzadeh, Jack Ghannam, Jeffrey Wang, Yana Al-Inaya, Gjystina Lumaj, Fereydoun Hormozdiari, Allen L. Feng, Jeremy D. Richmon, Daniel G. Deschler, Mark Alex Varvares, Daniel L. Faden, Derrick T. Lin, Hani Goodarzi

This study identifies oncRNAs as drivers of HPV-negative head and neck cancer and shows their potential for pre-diagnostic detection.

bioRxiv · Dec 25, 2025 · PreprintCancer Biology

Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma

Jong Chul Park, Nandini Pal Basak, Mateo Useche, Jun Seok Park, M. S. Ganesh, Amritha G Prabha, Chandra Reddy JayaPrakash, Mark Alex Varvares, Lori J. Wirth, William C. Faquin, Satish Sankaran, Srinivas Vinod Saladi

This study shows that PI3K pathway alterations in HPV-negative HNSCC are linked to poor outcomes and immune suppression, and that inhibiting PI3K can enhance immune response.

bioRxiv · Jul 2, 2024 · PreprintCancer Biology