Author

William C. Faquin

Harvard UniversityORCID 0000-0002-9043-7171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jong Chul ParkiD· 2 shared Lori J. WirthiD· 2 shared Peter M. SadowiD· 2 shared Aaron N. HataiD· 1 shared Adam von Paternos· 1 shared Amanda Jezek MartinotiD· 1 shared Amritha G Prabha· 1 shared Annie LiiD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Jong Chul ParkORCID

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Author profile →

4 papers

Recent·Most cited

Antibody peptide epitope conjugates for αPD-1 therapy-resistant head and neck squamous cell carcinoma

Yifang Shui, David G. Millar, Lukas M. Altenburger, Taylor T. Chrisikos, Michael J. Kalbfleisch, Aaron N. Hata, Peter M. Sadow, William C. Faquin, Amanda Jezek Martinot, Christopher M. Snyder, Mikaël J. Pittet, Sara Isabel Pai, Mark Cobbold, Thorsten R. Mempel

This study develops antibody-peptide epitope conjugates (APECs) to enhance anti-tumor activity in ICB-resistant HNSCC by leveraging viral peptide-loaded MHC I proteins and protease activity.

bioRxiv · Dec 2, 2025 · PreprintImmunology

Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association

Avishai Wizel, Matthew D. A. Spence, Michael Mints, William R. Britton, Ogoegbunam B. Okolo, Victoria Yu, Isabel Cioffi, Salvatore M. Caruana, Scott H. Troob, William C. Faquin, Derrick T. Lin, Itay Tirosh, Sidharth V. Puram, Anuraag S. Parikh, Yotam Drier

This study uses scRNA-seq to analyze HPV-related multiphenotypic sinonasal carcinoma and finds an association between HPV and MYB expression, with potential prognostic implications.

npj Precision Oncology · Nov 24, 2025Peer-reviewedCancer Biology

Reversible Downregulation of HLA Class I in Adenoid Cystic Carcinoma

Annie Li, Bianca L Gonda, Elizabeth M. Codd, Adam von Paternos, Dawn R. Mitchell, Markus D. Herrmann, Prinjali Kalyan, Samantha E. Flynn, Thuc Q Dzu, Chengzhuo Gao, Edwin Zhang, Julia J Mendel, Julia C Thierauf, Peter M. Sadow, Thomas Denize, , Anthony John Iafrate

This study identifies low HLA/B2M class I expression in ACC tumors and shows it can be reversed by interferon-ψ or STING agonists, suggesting a path for immunotherapy.

Journal for ImmunoTherapy of Cancer · Apr 1, 2025Peer-reviewedCancer Biology

Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma

Jong Chul Park, Nandini Pal Basak, Mateo Useche, Jun Seok Park, M. S. Ganesh, Amritha G Prabha, Chandra Reddy JayaPrakash, Mark Alex Varvares, Lori J. Wirth, William C. Faquin, Satish Sankaran, Srinivas Vinod Saladi

This study shows that PI3K pathway alterations in HPV-negative HNSCC are linked to poor outcomes and immune suppression, and that inhibiting PI3K can enhance immune response.

bioRxiv · Jul 2, 2024 · PreprintCancer Biology