Author

Anže Karlek

Universitätsmedizin Rostock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron HeldiD· 1 shared Alberto CataneseiD· 1 shared Andrea SalzingeriD· 1 shared Andreas HermanniD· 1 shared Annekathrin Rödiger· 1 shared Banaja P. DashiD· 1 shared Brian J. WaingeriD· 1 shared Dajana GroßmanniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Aaron HeldORCID

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1 paper

Recent·Most cited

RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS

Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, Dávid Brenner, Francisco J. Pan-Montojo, , Andreas Hermann

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

Advanced Science · Jan 28, 2026Peer-reviewedNeuroscience