Susanne Petri

Herpes simplex virus infection promotes ALS pathology through ICP0-mediated PML body disruption

This study shows HSV infection increases ALS risk and promotes TDP-43 pathology through ICP0-mediated disruption of PML bodies.

RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

Computing Linkage Disequilibrium Aware Genome Embeddings using Autoencoders

The paper introduces a method to compress genetic data using autoencoders that leverage linkage disequilibrium structure, achieving high reconstruction accuracy while reducing data size.

DJ-1 products glycolic acid and D-lactate restore deficient axonal trafficking and DNA damage response in FUS and SOD1-associated amyotrophic lateral sclerosis

The paper shows that glycolic acid and D-lactate restore axonal trafficking and DNA damage response in FUS and SOD1-ALS patient-derived motoneurons.

Multimodal layer modelling reveals in-vivo pathology in ALS

This study uses 7T-MRI and multimodal layer modeling to identify layer-specific pathology in early-stage ALS patients, revealing distinct iron and calcium accumulation patterns and their relationship to demyelination.

CDNF rescues motor neurons in three animal models of ALS by targeting ER stress

This study shows CDNF reduces ER stress and improves motor neuron survival in multiple ALS models, independent of genetic cause.

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation

This study shows that TDP43 mutations cause motor neuron degeneration in ALS through mechanisms unrelated to TDP43 aggregation or mislocalization.