Author

Stefanie Kretschmer

Technische Universität DresdenORCID 0000-0001-6571-570XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Min Ae Lee‐KirschiD· 3 shared Aaron HeldiD· 1 shared Adam Desrochers· 1 shared Adrian F. SchnelliD· 1 shared Alberto CataneseiD· 1 shared Alexander Henrici· 1 shared Andrea SalzingeriD· 1 shared Andreas HermanniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Min Ae Lee‐KirschORCID

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3 papers

Recent·Most cited

NeuroscienceAdvanced SciencePeer-reviewedJan 28, 2026

RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS

Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer…·Andreas Hermann

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

3 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintNov 9, 2025

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB

Nadja Lucas, Sophia Weidler, Antonia Eicher…·Min Ae Lee‐Kirsch

This study identifies truncating RELA variants causing autoinflammation and autoimmunity by disrupting NF-κB feedback control and immune homeostasis.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

BiochemistryMolecular CellPeer-reviewedMay 23, 2025

Structural Basis for OAS2 Regulation and its Antiviral Function

Veronika Merold, Indra Bekere, Stefanie Kretschmer…·Carina C. de Oliveira Mann

This study reveals the structural basis of OAS2 regulation and its antiviral function, showing how it discriminates RNA length and restricts viruses like coronaviruses.

10 citations

humanstructural biology

𝕏 PostBluesky