Francisco J. Pan-Montojo

RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

DJ-1 products glycolic acid and D-lactate restore deficient axonal trafficking and DNA damage response in FUS and SOD1-associated amyotrophic lateral sclerosis

The paper shows that glycolic acid and D-lactate restore axonal trafficking and DNA damage response in FUS and SOD1-ALS patient-derived motoneurons.

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

This study shows that extracellular alpha-synuclein toxicity in Parkinson's disease is independent of intracellular alpha-synuclein and linked to mitochondrial dysfunction.

A primeval mechanism of tolerance to desiccation based on glycolic acid saves neurons from ischemia in mammals by reducing intracellular calcium-mediated excitotoxicity

This study shows that glycolic acid protects neurons from ischemic damage by reducing calcium-mediated excitotoxicity during reperfusion in stroke models.

A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic development

This study shows that DJ-1 metabolites GA and DL can rescue fertility and mitochondrial dysfunction in multiple species, with GA having broader effects across models.

Physiological and pathological changes in the enteric nervous system of rotenone-exposed mice as potential early biomarkers for Parkinson's disease

This study examines how rotenone exposure affects the enteric nervous system in mice, identifying early physiological and structural changes that could serve as biomarkers for Parkinson's disease.