The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing
Anne Noom, Hülya Zeynep Oktay, Duncan M. Morgan, Sandy Kroh, Ana Kasapi, Agnes Ellinghaus, Merle Kochan, Olufemi Bolaji, Ralf Uecker, Robert Günther, M. Paula Bianchi, Christian H. Bucher, Alexander Hildebrandt, Simon F. Haas, Katharina Schmidt‐Bleek, , Georg N. Duda
This study identifies a cortical niche-specific macrophage subset that drives early osteoclastogenesis in bone healing through spatial immune-stromal interactions in young mice.
Nature Communications · Aug 27, 2026Peer-reviewedImmunology