Georg N. Duda

This paper develops 3D patterned alginate-collagen hydrogels that spatially guide endothelial cell invasion and proliferation by controlling collagen fibrillogenesis, degradation, and viscoelasticity.

This study identifies a cortical niche-specific macrophage subset that drives early osteoclastogenesis in bone healing through spatial immune-stromal interactions in young mice.

This study shows that ECM viscoelastic properties in bone fracture hematoma influence macrophage polarization, with high stress relaxation time promoting pro-inflammatory and low promoting anti-inflammatory responses.

This study shows that osmolality changes in bone marrow after fracture enhance mesenchymal stromal cell regeneration by altering ECM viscoelasticity and chromatin structure.

This paper shows that anisotropic hydrogel degradation patterns enhance hMSC alignment, mechanotransduction, and osteogenic differentiation compared to uniform materials.

The paper uses AI-based clustering to identify immune cell subtypes in fracture hematoma and bone marrow of mice, revealing differences between osteoporotic and non-osteoporotic groups.