Oncogene inactivation-induced senescence facilitates tumor relapse
Philipp Schmitt, Katrin Hönig, Maria Teresa Norcia, Marta F. Nogueira, Viktoria Flore, Inés Simó Vesperinas, Maria Villoro-Agud, Lushan Peng, Zuhal Safyürek, Mehreen Tariq, Ana Milojkovic, Kathleen Anders, Evelin Schröck, Sascha Sauer, Bora Uyar, , Thomas Blankenstein
This study shows that oncogene inactivation-induced senescence both limits tumor growth and promotes relapse by creating a pro-recurrence microenvironment.
Nature Communications · Jul 15, 2026Peer-reviewedCancer Biology