Thomas J. F. Blankenstein

This study shows that oncogene inactivation-induced senescence both limits tumor growth and promotes relapse by creating a pro-recurrence microenvironment.

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.

The paper identifies and ranks recurrent neo-epitopes in cancer using TCGA data and MHC class I binding prediction to prioritize candidates for immunotherapy.