P2Y2 purinergic receptor and DNA sensor cGAS dictate ionizing radiation-mediated proinflammatory macrophage activation
Ali Mostefa-Kara, Aurélia Deva Nathan, Audrey Paoletti, Anaïs Chapel, Emie Gutierrez-Mateyron, Thanh Trang Cao-Pham, Yara Bou Ghosn, Awatef Allouch, Jean‐Luc Perfettini
This study identifies a signaling pathway in macrophages where ionizing radiation induces mitochondrial fragmentation and cGAS activation, leading to proinflammatory activation, which is modulated by the P2Y2 purinergic receptor.
bioRxiv · Dec 19, 2024 · PreprintImmunology